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Contralateral adrenal metastasis

D Gillatt and S Barnard
 

A 68-year-old man presented with a twelve hour history of right loin pain and frank haematuria. He had had mild symptoms of bladder outflow obstruction for one year prior to presentation. On further questioning, he admitted that he had suffered from weight loss and night sweats for the past year. His medical history included a transient ischaemic attack one year previously. On examination, he was tender in the right loin but no masses were palpable. He was slightly anaemic (Hb 12.0 g/dl) but other routine admission blood tests were normal. A mid stream urine showed >100 red blood cells/high power field.

An intravenous urogram revealed an obstruction at the right pelvi-ureteric junction, and ultrasound scanning showed two solid masses arising from the mid and upper pole of the right kidney. A computed tomogram confirmed the presence of a right sided renal mass and showed a left adrenal mass. The renal mass was biopsied and hisotlogy confirmed a renal cell carcinoma.

 
scan4adrenalmetastasis
CT scan of the kidneys with intravenous contrast showing a solid mass in the right kidney and a mass anteromedial to the left kidney where one would expect the left adrenal.
 
A right radical nephrectomy was performed. The tumour was found to have extended into the inferior vena cava (IVC) up to the level of the hepatic veins. A tumour thrombus floated on a 'stalk' into the stream of the IVC. At first it was thought that this might be the end of a 'long line' (Polyurethane Drum-Cartridge Catheter, Abbott Ireland) inserted into the left cephalic vein, as it was felt floating within the lumen of the IVC and was of the same calibre as the catheter (see figure). The tumour thrombus was milked back to the ostium of the right renal vein and a small portion of the IVC was excised as it was directly involved.
 
figadrenalmetastastasis
 

The right adrenal gland was left in situ. The left adrenal mass was excised. Post operative adrenal function, as measured by blood pressure, serum electrolytes and short synacthen test was normal.

Contralateral adrenal metastasis from renal cell carcinoma is described in the literature1. These may present at the time of the primary tumour2, or up to 23 years later3,4. Selli et al. report 3 cases of simultaneous bilateral metastases5. The question of sparing of the ipsilateral adrenal gland during radical nephrectomy has been raised6, concluding that the ipsilateral gland can be spared when nephrectomies are performed for mid or lower pole tumours. Obviously this becomes more important when a synchronous contralateral adrenal metastases is detected.

 
References
 
1 Kessler OJ, Mukamel E, Weinstein R, Gayer E, Korichezky M and Servadio C (1998) Metachronous renal cell carcinoma metastasis to the contralateral adrenal gland. Urology 51(4): 539-543
2 Stein A, Mecz Y, Sova Y, Lurie M and Lurie A (1997) Synchronous and metachronous contralateral adrenal metastases from primary renal cell carcinoma. Urology International 58(1): 58-60
3 Mesurolle B, Mignon E, Travagli JP, Meignan P and Vanel D (1997) Late presentation of solitary contralateral adrenal metastasis of renal cell carcinoma. European Radiology 7(4): 557-558
4 Lemmers M, Ward K, Hatch T and Stenzal P (1989) Renal adenocarcinoma with solitary metastasis to the contralateral adrenal gland: report of 2 cases and review of the literature. J. Urol. 141(5): 1177-1180
5 Selli C, Carini M, Barbanti G and Turini D (1987) Simultaneous bilateral adrenal involvement by renal cell carcinoma: experience with three cases. J. Urol. 137(3): 480-482
6 O'Brien WM and Lynch JH (1987) Adrenal metastases by renal cell carcinoma. Incidence at nephrectomy. Urology 29(6): 605-607
 
 


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